Structural biology of factor VIIa/tissue factor initiated coagulation
نویسندگان
چکیده
منابع مشابه
Structural biology of factor VIIa/tissue factor initiated coagulation.
Factor VII (FVII) consists of an N-terminal gamma-carboxyglutamic acid domain followed by two epidermal growth factor-like (EGF1 and EGF2) domains and the C-terminal protease domain. Activation of FVII results in a two-chain FVIIa molecule consisting of a light chain (Gla-EGF1-EGF2 domains) and a heavy chain (protease domain) held together by a single disulfide bond. During coagulation, the com...
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ژورنال
عنوان ژورنال: Frontiers in Bioscience
سال: 2012
ISSN: 1093-9946,1093-4715
DOI: 10.2741/4066